Outer Membrane Proteins and Iron Uptake of Actinobacillus pleuropneumoniae
Jacqueline W. Chung, Mario Jacques and James W. Coulton
from: Pasteurellaceae: Biology, Genomics and Molecular Aspects (Edited by: Peter Kuhnert and Henrik Christensen). Caister Academic Press, U.K. (2008)
Abstract
Essential for the integrity and selective permeability of the membrane, outer membrane (OM) proteins of Gram-negative bacteria have critical roles in adaptation and infection within a host niche. With prominent roles in the pathogenesis of several bacterial pathogens, OM proteins have growing appeal as novel targets for anti-infectives and therapeutics. Members of the Pasteurellaceae family represent important human and animal pathogens that include Haemophilus , Actinobacillus , Pasteurella , and more recently, the newly added Mannheimia genera of organisms. Characterization of cell surface proteins has highlighted several redundant iron acquisition receptors for transferrin, siderophores, and heme/heme-containing proteins in Pasteurellaceae. In addition, the identification of several immunogenic lipoproteins and OM proteins has driven research for an effective cross-protective vaccine for these organisms. This chapter will review OM proteins and iron uptake systems of the swine pathogen, Actinobacillus pleuropneumoniae , causative agent of porcine pleuropneumonia, with reference to homologues in other members of Pasteurellaceae read more ...
