Protein Secretion in Pasteurellaceae
Scott C. Kachlany and Nataliya V. Balashova
from: Pasteurellaceae: Biology, Genomics and Molecular Aspects (Edited by: Peter Kuhnert and Henrik Christensen). Caister Academic Press, U.K. (2008)
Protein secretion is an essential process for all cells. Gram negative bacteria use different secretion systems to transport a variety of proteins across their double membrane and into the extracellular environment. In general, bacterial protein secretion systems are complex machineries made up of many components that act together to transport molecules out of the cell. There are essentially three classes of proteins that the members of the Pasteurellaceae secrete: Toxins, Adhesins, and Proteases. Toxins produced by the members of the Pasteurellaceae include the highly host-specific RTX toxins and cytolethal distending toxins. Adhesins include the self-secreting autotransporters, the widespread Flp pili, and type IV pili. The proteases produced by these members include the antibody-cleaving immunoglobulin and bi-functional HAP proteases read more ...