Hendra and Nipah Viruses
Michael K. Lo, Melissa M. Coughlin and Paul A. Rota
from: The Biology of Paramyxoviruses (Edited by: Siba K. Samal). Caister Academic Press, U.K. (2011)
Nipah and Hendra viruses comprise the genus Henipavirus and are highly pathogenic paramyxoviruses, which cause fatal encephalitis and respiratory disease in humans. Since their respective initial outbreaks in 1998 and 1994, they have continued to cause sporadic outbreaks resulting in fatal disease. Due to their designation as Biosafety Level 4 pathogens, the level of containment required to work with live henipaviruses is available only to select laboratories around the world. This chapter provides an overview of henipaviruses in regards to their diagnosis, clinical features, and epidemiology, while highlighting recent studies which have expanded our knowledge of their molecular biology, pathogenesis, and control with novel antiviral therapeutics read more ...