Newcastle Disease and Related Avian Paramyxoviruses
Siba K. Samal
from: The Biology of Paramyxoviruses (Edited by: Siba K. Samal). Caister Academic Press, U.K. (2011)
Newcastle disease (ND) is one of the most important diseases of poultry worldwide. Virulent Newcastle disease virus (NDV) infections may have flock mortality rates up to 100%. The economic impact is not only due to loss of birds, but also due to trade restrictions and embargoes placed on areas and countries where the outbreaks have occurred. In many developing countries ND is endemic and the disease has the greatest impact on villages where the livelihood of people depend on poultry farming. ND probably has the most impact on the world's economy than any other animal disease. NDV belongs to avian paramyxovirus serotype-1 (APMV-1) and is the most characterized member among the nine APMV serotypes. In recent years, NDV has drawn a lot of research interest not only because it is an important pathogen of poultry, but it is also an oncolytic agent and is a potential vaccine vector for human and animal uses. Currently, very little is known about the molecular biology and pathogenicity of APMV-2 to -9, but our knowledge on these serotypes is rapidly expanding with the availability of complete genome sequences of all APMV serotypes read more ...