The Parainfluenza Virus Simian Virus 5
Griffith D. Parks, Mary J. Manuse, and John B. Johnson
from: The Biology of Paramyxoviruses (Edited by: Siba K. Samal). Caister Academic Press, U.K. (2011)
Many of the fundamental properties of paramyxovirus biology are founded on studies of the prototype negative strand RNA virus Simian Virus 5 (SV5). This includes the basic understanding of the structure of the paramyxovirus particle, as well as the structure and function of the viral hemagglutinin-neuraminidase attachment protein and viral fusion protein. The discovery of the unique mechanism by which many paramyxoviruses express the viral P and V proteins by non-templated addition of G residues was first described for SV5. This prototype paramyxovirus also employs unique biological processes to evade host immune responses, including the blocking host cell sensors that recognize virus replication products and the targeted degradation of STAT1, a host cell protein that is integral to interferon signaling. Based on this rich history of fundamental discoveries, future work will be focused on interactions of SV5 with the immune system and development of novel SV5-based vectors read more ...