Steven Rubin and Corinne Vandermeulen
from: The Biology of Paramyxoviruses (Edited by: Siba K. Samal). Caister Academic Press, U.K. (2011)
Mumps is a contagious infectious disease caused by mumps virus, a Rubulavirus of the Paramyxoviridae family. Mumps outbreaks were common in the prevaccine era, with nearly everyone having been exposed by adolescence based on the presence of virus-specific antibody. The hallmark of infection is the painful enlargement of the parotid gland, and although perceived as a benign childhood disease, mumps was the leading cause of aseptic meningitis and sensorineural deafness prior to the adoption of widespread vaccine use. The changing epidemiology of mumps in the postvaccine era has renewed interest in the virus, specifically in regards to the biology of the virus, development of new diagnostic tools, investigation of immune responses following vaccination and the epidemiological effects of mumps vaccination in large populations. This chapter reviews the current knowledge of mumps virus as an infectious agent, the immune response to infection and its epidemiology, prevention and control measures read more ...