Caister Academic Press

The Molecular Basis of Host Defense Mechanisms in Oral Disease

Alex B. Berezow, Lijian Jin and Richard P. Darveau
from: Molecular Oral Microbiology (Edited by: Anthony H. Rogers). Caister Academic Press, U.K. (2008)


The innate defense status of clinically healthy periodontal tissue is highly orchestrated. For example, histochemical, immunohistochemical, and in situ studies examining clinically healthy human periodontal tissue have revealed that neutrophils routinely transit through periodontal tissue from the highly vascularized tissue surrounding the tooth root surface to the gingival crevice located outside of periodontal tissue. Several innate defense response mediators including IL-8, ICAM, and E-selectin, have been shown to be expressed in clinically healthy tissue and have been proposed to facilitate neutrophil trafficking. Both host developmental programs and the host protective response to oral bacterial commensal colonization contribute to the highly organized tissue structure and molecular expression of select innate defense components read more ...
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