The X-chromosome Archetype for Noncoding RNA Regulation of the Epigenome
Daniel H. Kim and Jeannie T. Lee
from: Non-coding RNAs and Epigenetic Regulation of Gene Expression: Drivers of Natural Selection (Edited by: Kevin V. Morris). Caister Academic Press, U.K. (2012)
X-chromosome inactivation provides a model for discovering the still emerging functions of noncoding RNAs, which exhibit diverse roles in regulating the epigenome. Combining recent insights into X-chromosome noncoding RNAs with the advent of next-generation sequencing technologies promises many new discoveries in interrogating the functions of noncoding RNAs at the genomic level. Global RNA-protein interaction information is readily available through utilizing RNA immunoprecipitation followed by high-throughput sequencing (RIP-Seq), which has recently uncovered the diversity of the noncoding Polycomb transcriptome. In this chapter, we discuss noncoding RNAs of the X-inactivation center that have provided unique insights into RNA molecules as molecular switches, guides and tethers to the epigenome, and key participants in diverse regulatory pathways, including RNA interference and Polycomb silencing read more ...