Novel Insights from Re-sequencing of Human Exomes Through NGS
Jun Li, Tao Jiang, Xu Yang and Jun Wang
from: Next-generation Sequencing: Current Technologies and Applications (Edited by: Jianping Xu). Caister Academic Press, U.K. (2014)
The advent of exome sequencing has opened a new door of NGS application in human diseases research. As an efficient and cost-effective method, exome sequencing using NGS platforms has brought human disease research into a new era. Since many human diseases are caused by mutations in exons, exome sequencing presents a powerful approach to study human diseases. Several exome capture kits have been developed to promote exome sequencing. The wide application of exome sequencing in recent years has significantly boosted scientific discoveries. Through bioinformatics analysis after exome sequencing, many genes have been found related to human diseases. As NGS price decreases rapidly, exome sequencing is expected to become a routine method for academic and clinical use read more ...