Innate Immune Recognition of Neisseria meningitidis and Neisseria gonorrhoeae
Daniel C. Stein, Julia B. Patrone and Samuel Bish
from: Neisseria: Molecular Mechanisms of Pathogenesis (Edited by: Caroline Genco and Lee Wetzler). Caister Academic Press, U.K. (2010)
The existing paradigm in neisserial infections is that these pathogens present a diverse, varying cell surface, and that one of the functions of this variability is that it allows them to avoid the killing actions of the hosts' innate immune system. In this chapter, we will define the important features of the innate immune system as it relates to neisserial disease, review the role of the variable cell surface antigens of N. gonorrhoeae and N. meningitidis in eliciting responses from various host cells, and provide some insights into the molecular basis of disease. We will describe what features are essential on the bacterium for initiating colonization in various anatomical locations and in the different sexes, and review how the host responds to these colonization events (disease vs asymptomatic colonization). We will also review the molecular mechanisms by which cells of the innate immune system become activated, and how different activation mechanisms can lead to different disease outcomes read more ...