Caister Academic Press

Gonococcal Biofilms

Michael Apicella, Megan L. Falsetta, Ryan Neil and Christopher Steichen
from: Neisseria: Molecular Mechanisms of Pathogenesis (Edited by: Caroline Genco and Lee Wetzler). Caister Academic Press, U.K. (2010)


Neisseria gonorrhoeae is an exclusive human pathogen. Our studies have demonstrated that it utilizes two distinct mechanisms for entry into human urethral and cervical epithelial cells involving different bacterial surface ligands and host receptors. Our recent studies have demonstrated that the gonococcus can form biofilms on glass surfaces and over human cells. In this chapter, we provided details of evidence for formation of gonococcal biofilms on human cervical epithelial cells during natural disease and provide further evidence that outer membrane blebbing by the gonococcus is crucial in biofilm formation over human cervical epithelial cells read more ...
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