Caister Academic Press

Current Molecular and Emerging Nanobiotechnology Approaches for the Detection of Microbial Pathogens

Jacques Theron, Thomas Eugene Cloete and Michele de Kwaadsteniet
from: Nanotechnology in Water Treatment Applications (Edited by: T. Eugene Cloete, Michele de Kwaadsteniet, Marelize Botes and J. Manuel López-Romero). Caister Academic Press, U.K. (2010)

Abstract

An adequate supply of safe drinking water is one of the major prerequisites for a healthy life, but waterborne diseases is still a major cause of death in many parts of the world, particularly in young children, the elderly, or those with compromised immune systems. As the epidemiology of waterborne diseases is changing, there is a growing global public health concern about new and reemerging infectious diseases that are occurring through a complex interaction of social, economic, evolutionary, and ecological factors. An important challenge is therefore the rapid, specific and sensitive detection of waterborne pathogens. Presently, microbial tests are based essentially on time-consuming culture methods. However, newer enzymatic, immunological and genetic methods are being developed to replace and/or support classical approaches to microbial detection. Moreover, innovations in nanotechnology and nanosciences are having a significant impact in biodiagnostics, where a number of nanoparticle-based assays and nanodevices have been introduced for biomolecular detection. Accordingly, current and emerging molecular approaches for the detection of microbial pathogens as well as nanobiotechnologies that that will extend the limits of current molecular diagnostics are discussed read more ...
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