Caister Academic Press

Specialised Protein Secretion Systems of Mycobacteria

Wilbert Bitter, Edith N.G. Houben and Joen Luirink
from: Mycobacterium: Genomics and Molecular Biology (Edited by: Tanya Parish and Amanda Brown). Caister Academic Press, U.K. (2009)


Mycobacteria have a highly complex cell wall. Specialised secretion systems are therefore required to transport proteins across this cell wall. However, genome analysis showed that, apart from the omnipresent Sec and Tat systems, all of the known secretion pathways of other bacteria are absent. Mycobacteria do have a second SecA protein (SecA2) that is involved in the extracellular accumulation of a specific protein subset. In addition, a new secretion pathway was recently identified that is responsible for the secretion of various proteins into the culture supernatant. This pathway is present in multiple copies in the mycobacteria and has been named the type VII secretion pathway. Both the SecA2 and the type VII secretion systems are discussed in this chapter read more ...
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