Caister Academic Press

The Eukaryotic-like Serine/Threonine Protein Kinase Family in Mycobacteria

Nicole Scherr and Jean Pieters
from: Mycobacterium: Genomics and Molecular Biology (Edited by: Tanya Parish and Amanda Brown). Caister Academic Press, U.K. (2009)


Mycobacteria have a complex life style comprising different environments and developmental stages. Signal sensing and transduction leading to cellular responses must be tightly regulated to allow survival under variable conditions. Prokaryotes normally regulate their signal transduction processes through two-component systems, however, the genome sequence of Mycobacterium tuberculosis revealed a large number of eukaryotic-like serine/threonine kinases. It is becoming clear that in M. tuberculosis, many of these kinases are involved in the regulation of metabolic processes, transport of metabolites, cell division and virulence. This chapter summarizes the current knowledge on eukaryotic-like serine/threonine protein kinases in mycobacteria. Investigating the biochemistry and physiology of these enzymes may lead to a better understanding of the signalling networks in mycobacteria read more ...
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