Caister Academic Press

Oxygen, Nitric Oxide, and Carbon Monoxide Signaling

Martin I. Voskuil, Ryan W. Honaker and Adrie J.C. Steyn
from: Mycobacterium: Genomics and Molecular Biology (Edited by: Tanya Parish and Amanda Brown). Caister Academic Press, U.K. (2009)


Mycobacterium tuberculosis is an aerobe that can survive extended periods of anaerobiosis. The bacillus responds to inhibition of respiration during hypoxic conditions as well as exposure to NO and CO by the induction of over 60 genes, referred to as the "dormancy regulon". Control of the dormancy regulon by NO and CO, not just hypoxia, is mediated by a three component regulatory system composed of two sensors, DosT and DosS and a transcriptional regulator DosR. The dormancy proteins are part of a programmed strategy employed by the bacilli to survive in the absence of aerobic respiration. In this review we will revisit the role of oxygen in M. tuberculosis physiology, the regulation of the dormancy regulon, the function of regulon proteins, the mechanisms DosT and DosS employ to sense diatomic gases, the role of the dormancy program in animal models of infection and in human latent infection, and will provide an updated comprehensive list of regulon genes read more ...
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