Bacterial Membranes as Drug Targets
Alvin Lo, Gaetano Castaldo and Han Remaut
from: Bacterial Membranes: Structural and Molecular Biology (Edited by: Han Remaut and Rémi Fronzes). Caister Academic Press, U.K. (2014)
Bacterial membranes play a pivotal role in maintaining cell integrity, in chemical energy generation and in the interplay between bacteria and their environment. Given their indispensible functions in bacterial physiology and metabolism, it comes as no surprise that bacterial membranes and membrane-associated biosynthetic and metabolic pathways form important targets for antibacterial compounds. Bacterial membranes and membrane-associated proteins and processes have formed the targets of natural antibiotics as well as promising starting points for the search and design of new synthetic antibacterials. In this chapter, we provide a review of existing examples of membrane-targeting antibiotics as well as an overview of the pathways that are currently under investigation for chemical knockdown read more ...