Caister Academic Press

The Role Of Lipid Composition on Bacterial Membrane Protein Conformation and Function

Vinciane Grimard, Marc Lensink, Fabien Debailleul, Jean-Marie Ruysschaert and Cedric Govaerts
from: Bacterial Membranes: Structural and Molecular Biology (Edited by: Han Remaut and Rémi Fronzes). Caister Academic Press, U.K. (2014)


Cellular, biochemical and biophysical studies have shown over the last years that membrane proteins interact intimately with the lipid bilayer and that the structure and the activity of these proteins can be modulated by the type of lipids that surround them. Studies have demonstrated that physico-chemical properties of the membrane affect protein function. In fact some proteins directly sense the membrane properties, such as fluidity, tension, curvature stress or hydrophobic mismatch, for example as a signal for temperature or osmotic stress. In other cases, specific interactions between defined protein motifs and given lipids have been evidenced. These interactions often fulfill structural and functional role and are intimately linked to the biological function of membrane proteins. This chapter aims at summarizing the elaborate interplay existing between proteins and lipids and the influence of both specific interactions and bulk properties of the membrane on the stability, the structure and the activity of bacterial membrane proteins read more ...
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