Caister Academic Press

Outer Membrane Protein Biosynthesis: Transport and Incorporation of OM Proteins (in)to the OM bilayer

Kelly H. Kim, Suraaj Aulakh and Mark Paetzel
from: Bacterial Membranes: Structural and Molecular Biology (Edited by: Han Remaut and Rémi Fronzes). Caister Academic Press, U.K. (2014)


The outer membrane is a unique structural feature of Gram-negative bacteria. Within the outer membrane reside β-barrel outer membrane proteins that serve many important functions, such as nutrient uptake, virulence and cell signaling. Proper folding and assembly of these proteins are therefore essential for cell viability. Gram-negative bacteria possess a specialized proteinaceous machine known as the BAM (β-barrel assembly machinery) complex that is responsible for the proper assembly of β-barrel proteins into the outer membrane. This chapter summarizes the current status of knowledge about outer membrane protein biosynthesis, and the significant progress that has been made towards understanding the structure and function of the bacterial BAM complex read more ...
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