Inhibitors of DNA Topoisomerases as Potential Antileishmanial Agents
Sayan Chowdhury and Hemanta K. Majumder
from: Leishmania: Current Biology and Control (Edited by: Subrata Adak and Rupak Datta). Caister Academic Press, U.K. (2015) Pages: 193-214.
Leishmaniasis is a dynamic disease which is gradually spreading, with the high mortality rates and involved in the economic loss resulting from morbidity. The disease is mainly prevalent in the tropical and subtropical areas. The enormous development of molecular and cellular biology in recent times have provided opportunities for discovering newer molecular targets for drug designing, which now forms a rational basis for the development of improved anti-parasitic therapy. The diversity found in the life cycle of these organisms must be directed by genetic events, wherein topoisomerases play an important role in cellular processes affecting the topology and organization of intracellular DNA. Recently, emergence of the bi-subunit topoisomerase I in the kinetoplastid family has brought a new twist in topoisomerase research related to evolution, functional conservation and as a potential target that can be exploited in drug designing and development of new intervention strategies. Therefore, understanding the biology of kinetoplastid topoisomerases and the components and steps involved in this intricate process provide opportunities for target based drug designing against protozoan parasitic diseases. This review summarizes the biology of kinetoplastid topoisomerases, which are the key molecular targets in antileishmanial chemotherapy read more ...