Caister Academic Press

Role of STAT Signaling in Immunity to Leishmaniasis

Steve Oghumu, James Stock, Cesar Terrazzas, Gayathri Natarajan, Sanjay Varikuti and Abhay R Satoskar
from: Leishmania: Current Biology and Control (Edited by: Subrata Adak and Rupak Datta). Caister Academic Press, U.K. (2015) Pages: 107-120.


The JAK/STAT signaling pathway is a principal mediator of the effects of cytokines on immune cells and therefore plays a major role in the orchestration of immunological responses to an infectious challenge. The STAT family is comprised of seven genes that code for STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6, and most of these STATs as well as their associated signaling mediators have been shown to be critical in immunity and/or pathogenesis of various forms of Leishmania infection. Leishmania are also known to exploit the JAK/STAT signaling pathway to favor parasite establishment, growth and replication. Understanding how Leishmania modulates this host intracellular pathway could lead to the development of more effective therapeutic approaches against leishmaniasis. In this chapter we will discuss the importance of STATs and their signaling ligands in various forms of Leishmania infection and how the parasite has exploited this intracellular network to evade anti-parasitic immune responses and facilitate survival within the host. We will also briefly address how our knowledge of these mechanisms can aid in the development of effective therapeutic strategies in the management of leishmaniasis read more ...
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