Elucidating the Strategies of Immune Evasion by Leishmania
Supriya Srivastav, Anindita Ukil and Pijush K. Das
from: Leishmania: Current Biology and Control (Edited by: Subrata Adak and Rupak Datta). Caister Academic Press, U.K. (2015) Pages: 93-106.
The protozoa Leishmania species are obligate intracellular parasites that harbour in the macrophages of their host. In order to inhabit an intracellular niche, they have evolved various means to attenuate and/or subvert how their host cell integrates signals from the external 'immune' environment. Since macrophages being the first line of defence in the immune system are specialized for the identification and destruction of invading pathogens by triggering an innate immune response, Leishmania have evolved a range of mechanisms for suppressing some critical macrophage activities. This is achieved either by employing strategies to inhibit proteins that play a positive role in immune cell activation or by activation of molecules that govern the negative regulation of immune cell signaling and function. This chapter highlights the strategies employed by Leishmania to suppress macrophage defence mechanism to create a favourable niche which aids the parasite in intracellular growth and virulence read more ...