Role of Iron in Leishmania-Macrophage Interaction
Kavita Bharati, Saswat Kumar Bal, Shalini Saini, Vikash Bhardwaj and Chinmay K. Mukhopadhyay
from: Leishmania: Current Biology and Control (Edited by: Subrata Adak and Rupak Datta). Caister Academic Press, U.K. (2015) Pages: 37-54.
Iron is an essential micronutrient for most forms of life because of its vital role as a redox cofactor of proteins requiring for critical cellular processes. Being equally essential for survival of the host and pathogen, iron has taken its justified role in the immune status of the former and the virulence capacity of the later. Acquiring iron is a fundamental step in the development of a pathogen within the host, while host cells are known to implement several iron sequestration policies to encounter the different invasion strategies of pathogens. These illustrate the longstanding and ongoing battle for iron between host and pathogen in the evolution. This chapter describes the understanding of the role of iron in interaction between Leishmania and its mammalian host read more ...