Caister Academic Press

Heat Shock Proteins of Leishmania: Chaperones in the Driver's Seat

Joachim Clos and Antje Hombach
from: Leishmania: Current Biology and Control (Edited by: Subrata Adak and Rupak Datta). Caister Academic Press, U.K. (2015) Pages: 17-36.


The roles of so-called heat shock proteins (HSPs) in Leishmania was long assumed to revolve around protective functions against temperature and adverse milieu inside macrophages. In recent years, however, a picture has emerged that shows heat shock proteins and co-chaperone proteins as effectors and regulators of signal transduction and immune evasion pathways, possibly compensating for the lack of regulated gene expression and regulatory factors in Leishmania spp read more ...
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