Modulation of Host Cell miRNA Expression During Leishmania Infection and Emergence of miRNA as a New Therapeutic Molecule
Suvendra N.Bhattacharyya, June Ghosh and Sudarshana Basu
from: Leishmania: Current Biology and Control (Edited by: Subrata Adak and Rupak Datta). Caister Academic Press, U.K. (2015) Pages: 1-16.
The kinetoplastid protozoan Leishmania donovani infects liver and spleen of the mammalian hosts and resides inside the tissue macrophages. The pathogen resides within the parasitophorous vacuoles, the specialized subcellular structures in the infected macrophage cells, and affects gene expression in infected and also the non-parasitized neighboring cells. Expression of miRNAs, the tiny regulatory RNA of eukaryotic cells, also gets altered in Leishmania infected macrophages and also in the hepatocytes of infected mouse liver. Restoration of expression of miR-122, a hepatic miRNA that regulate serum cholesterol and get reduced upon Leishmania infection in liver, is associated with increase in serum cholesterol level and lowering of liver parasite load. In this chapter we have discussed the importance of host cell miRNA alteration and its mechanism in the context of visceral leishmaniasis read more ...