Drug Resistance in Leishmania
Marc Ouellette, Jolyne Drummelsmith, Philippe Leprohon, Karima El Fadili, Aude Foucher, Baptiste Vergnes and Danielle Légaré
from: Leishmania: After The Genome (Edited by: Peter J. Myler and Nicolas Fasel). Caister Academic Press, U.K. (2008)
Leishmaniasis is controlled mostly through the use of chemotherapy. Pentavalent antimonials have long been the mainstay treatment but resistance to this class of drugs is increasing throughout the endemic regions. Other useful drugs against leishmaniasis include amphotericin B, miltefosine, and to a lesser extent, pentamidine. Few novel drugs are currently in development. Whole genome approaches such as detection of gene amplification events, functional cloning, DNA microarrays and proteomics have already led to an increased understanding of resistance mechanisms induced under laboratory conditions. The current challenge is to understand resistance mechanisms occurring in the field, and whole genome approaches will be useful in this endeavour read more ...