The Dot/Icm Type IVB Secretion System of Legionella
Carr D. Vincent and Joseph P. Vogel
from: Legionella: Molecular Microbiology (Edited by: Klaus Heuner and Michele Swanson). Caister Academic Press, U.K. (2008)
Abstract
The major virulence system of Legionella pneumophila is a specialized secretion system encoded by twenty-six dot/icm genes. This secretion machine is classified as a type IVB secretion system due to its homology to the transfer apparatus of IncI conjugative plasmids. In Legionella, the Dot/Icm secretion system is used to export a large number of protein substrates into the cytoplasm of phagocytic cells, thereby allowing Legionella to survive and replicate within these normally bacteriocidal cells read more ...
