Caister Academic Press

S-Layer Proteins from Lactobacilli: Biogenesis, Structure, Functionality and Biotechnological Applications

Mariano Malamud, Patricia A. Bolla, Paula Carasi, Esteban Gerbino, Andrea Gómez-Zavaglia, Pablo Mobili and María de los Angeles Serradell
from: Lactobacillus Genomics and Metabolic Engineering (Edited by: Sandra M. Ruzal). Caister Academic Press, U.K. (2019) Pages: 105-130.


The S-layer is a (glyco)-proteinaceous envelope made up of subunits that self-assemble to form a two-dimensional lattice that covers the surface of different species of Bacteria and Archaea. The S-layer (glyco)-proteins have been shown to possess exceptional physicochemical properties which make them unique organizational structures with high potential application in different areas of biotechnology. It represents a very interesting model system for studying the processes involved in the synthesis, secretion and assembly of extracellular proteins. Among bacteria, its presence has been demonstrated in many species of lactobacilli, some of which could be considered as probiotic microorganisms. In this chapter, we will discuss the most relevant and updated concepts regarding genetics, structural features, cell wall- and self-assembly, functionality and biotechnological applications of the S-layer proteins from lactobacilli read more ...
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