Caister Academic Press

Interactions of Lactobacillus with the Immune System

Denny Demeria and Karen Madsen
from: Lactobacillus Molecular Biology: From Genomics to Probiotics (Edited by: Åsa Ljungh and Torkel Wadström). Caister Academic Press, U.K. (2009)


Lactobacilli have been used for centuries with the intent to produce a health benefit in the human host. Interactions between the host and lactobacilli involve lactobacilli-induced alteration of gene expression in gut epithelial and immune cells, with the subsequent modulation of both mucosal and systemic immune function. Effects of lactobacilli are concentration and species and strain-dependent. Lactobacilli are critical in establishing a state of immunological homeostasis within the host. Beneficial effects exerted by lactobacilli bacteria in the treatment of human disease may be broadly classified as those effects which arise due to activity in the large intestine and are related to colonization or inhibition of pathogen growth; and those effects which arise in both the small and large intestine, and are related to enhancement of the host immune response and intestinal barrier function read more ...
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