Surface Proteins of Lactobacillus Involved in Host Interactions
Jenni Antikainen, Timo K. Korhonen, Veera Kuparinen, Takahiro Toba and Stefan Roos
from: Lactobacillus Molecular Biology: From Genomics to Probiotics (Edited by: Åsa Ljungh and Torkel Wadström). Caister Academic Press, U.K. (2009)
Specific recognition of host components is central in bacterial adhesion and colonization at host surfaces as well as in bacterial interaction with physiological and immunological processes of the host. Isolates of Lactobacillus express a variety of adhesive surface proteins, many of which are multifunctional adhesins or also involved in physiological processes in the bacteria. These adhesins can be grouped as S-layer proteins, proteins with the LPXTG surface-anchoring motif, surface-localized housekeeping proteins, as well as transporter proteins. Recognized targets for lactobacillar adhesins include epithelial and phagocytic cells, extracellular matrices, mucins, and circulating components. A more detailed, mechanistic knowledge of lactobacillar adhesion proteins will help to understand their role in colonization and to develop their probiotic use read more ...