Quality Control of Protein Structure in Lactic Acid Bacteria
Shinya Sugimoto and Kenji Sonomoto
from: Lactic Acid Bacteria and Bifidobacteria: Current Progress in Advanced Research (Edited by: Kenji Sonomoto and Atsushi Yokota). Caister Academic Press, U.K. (2011)
In order to maintain cell viability, it is essential to maintain protein homeostasis under normal conditions and during injury or stress. A network of highly conserved molecular chaperones and proteases controls the quality of cellular proteins by repairing and degrading abnormal proteins. The recently completed genome sequencing, combined with the development of advanced molecular techniques, has enabled us to identify these protein quality control systems in various lactic acid bacteria (LAB). Furthermore, mutational and biochemical studies are providing new insights into the physiological significance of protein quality control systems in LAB read more ...