miRNA Modulation of Insect Virus Replication
Verna Monsanto-Hearne and Karyn N. Johnson
from: Insect Molecular Virology: Advances and Emerging Trends (Edited by: Bryony C. Bonning). Caister Academic Press, U.K. (2019) Pages: 61-82.
The outcome of virus infection in insects is impacted by regulation of both host and virus gene expression. A class of small RNAs called microRNAs (miRNA) have emerged as important regulators of gene expression that can influence the outcome of virus infection. miRNA regulation occurs at a comparatively late stage of gene expression, allowing for rapid control and fine-tuning of gene expression levels. Here we discuss the biogenesis of miRNAs from both host and virus genomes, the interactions that lead to regulation of gene expression, and the miRNA-mRNA interactions that lead to either antivirus or provirus consequences in the course of virus infection in insects read more ...