Polymerase Structure and Function
Mark Bartlam, Zhiyong Lou, Yingfang Liu and Zihe Rao
from: Influenza: Molecular Virology (Edited by: Qinghua Wang and Yizhi Jane Tao). Caister Academic Press, U.K. (2010)
The influenza virus RNA-dependent RNA polymerase is a heterotrimeric complex (PA, PB1 and PB2) with multiple enzymatic activities for catalyzing viral RNA transcription and replication. Its critical roles in the influenza virus life cycle and high sequence conservation suggest it should be a major target for therapeutic intervention. However, until very recently, functional studies and drug discovery targeting the influenza polymerase have been hampered by the lack of three-dimensional structural information. In this chapter, we will review the recent progress in the structure and function of the influenza polymerase, and discuss prospects for the development of anti-influenza therapeutics read more ...