The Application of Proteomics Technology to Helicobacter pylori-associated Gastroduodenal Disease: State-of-the-Art and Future Clinical Potentials
Ming-Shiang Wu, Lu-Ping Chow, Jaw-Town Lin and Shyh-Horng Chiou
from: Helicobacter pylori: Molecular Genetics and Cellular Biology (Edited by: Yoshio Yamaoka). Caister Academic Press, U.K. (2008)
Abstract
The current disease paradigm suggests that host genetics and Helicobacter pylori virulence play an important role in modulation of the final outcome. Elucidation of the bidirectional relationship between the host and bacteria is thus essential to clarify pathogenesis and development of new prevention and treatment strategies. Proteomics technology has provided unprecedented opportunity to comprehensively survey a cell's translational landscape and may allow in-depth analyses of host and pathogen interaction, either separately or interactively. Using this high-throughput platform and taking advantage of complete sequences for both the H. pylori and human genome in the database, some promising results and important information have been reported. Among the recent contributions relating to H. pylori, this review focuses on proteomics-based characterization of intrinsic and extrinsic perturbations and strain differences of H. pylori, epithelial cell response to H. pylori infection, identification of diagnostic/prognostic biomarkers, and uncovering of immunogenic proteins for vaccine targets. Future combination of evolving new proteomics technologies with clinical phenotypes and genotypes information will enhance the understanding of disease pathogenesis, lead to a more precise predication of variable outcomes, and facilitate the development of effective biomarkers for diagnosis, treatment and prevention of H. pylori infection read more ...
