Metal Metabolism and Transport in Helicobacter pylori
Jeroen Stoof, Clara Belzer and Arnoud H.M. van Vliet
from: Helicobacter pylori: Molecular Genetics and Cellular Biology (Edited by: Yoshio Yamaoka). Caister Academic Press, U.K. (2008)
The members of the genus Helicobacter are among the most successful colonizers of the mammalian gastrointestinal and hepatobiliary tract, and are thought to have co-evolved during the development of the mammalian digestive system. The best studied Helicobacter species is the human pathogen H. pylori, which colonises the gastric mucosa, and this colonization results in chronic gastritis which may develop into peptic ulcer disease or gastric adenocarcinoma. The longevity of gastric colonization suggests that H. pylori must be able to cope with the different stresses encountered in the gastric mucosa, like low pH and restriction of essential metals like iron and nickel. In this chapter we will review the current knowledge on the role of metal metabolism in the physiology of H. pylori, and discuss the contribution of the regulatory mechanisms involved in controlling metal metabolism in the adaptation of H. pylori to its gastric niche read more ...