Vaccines that Induce Cellular Immunity
Britta Wahren and Margaret A. Liu
from: AIDS Vaccine Development: Challenges and Opportunities (Edited by: Wayne Koff, Patricia Kahn and Ian D. Gust). Caister Academic Press, U.K. (2007)
Abstract
The ability to induce cell-mediated immunity (CMI) is widely thought to be an important property of any potential AIDS vaccine or immunotherapy. The rationale is based on many observations, including: (1) a demonstrated role for CMI in containing HIV after infection; and (2) the ability of T-cells to target viral epitopes that may be more highly conserved amongst different strains (both intra-clade and cross-clade) than the Env structures that have been evaluated clinically as potential vaccine immunogens. This chapter examines the design issues specific for vaccines intended to induce cellular immunity against HIV/AIDS, discusses characteristics of these approaches (most of which are gene-based) and gives an overview of the different candidates under development read more ...
