NS4B Targets and Inhibitors
Menashe Elazar and Jeffrey S. Glenn
from: Hepatitis C: Antiviral Drug Discovery and Development (Edited by: Seng-Lai Tan and Yupeng He). Caister Academic Press, U.K. (2011)
Hepatitis C virus (HCV) non-structural protein 4B (NS4B) is emerging as a major target for antiviral intervention. NS4Bs crucial role in different aspects of HCVs life cycle and newly identified functions of this protein enabled development of specific assays that were utilized for high-throughput small molecule screens, which in turn lead to identification of small molecules inhibitors of NS4B functions and HCV replication some of which are undergoing clinical evaluation and preclinical development. In this review we highlight the recent identification of small molecule inhibitors that targets NS4Bs RNA binding activity and an AH-mediated membrane interaction. We further discuss the potential of other candidate activities or domains within NS4B that may serve as targets for antiviral intervention read more ...