Caister Academic Press

Hepatitis C Virus Related Assays

Zhuhui Huang, Zhaohui Cai and Michael G. Murray
from: Hepatitis C: Antiviral Drug Discovery and Development (Edited by: Seng-Lai Tan and Yupeng He). Caister Academic Press, U.K. (2011)


Development of appropriate assays and model systems in Hepatitis C virus (HCV) research has been critical to the initial discovery of the etiological agent as well as having been integral to the discovery and development of antiviral therapies over the years that followed. The vast amount of protein structural data that has been developed greatly facilitated and guided the chemistry of antiviral development. Meanwhile, various cell-based assays have been developed to further enhance our understanding of HCV virology and virus-host interactions, and to be used for development of potential therapeutics for intervention. In this chapter, we will highlight various cell-based assays and biochemical assays based on purified proteins in well characterized buffer systems, made possible through molecular virology read more ...
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