An Overview of the Hepatitis C Virus Life Cycle
Timothy L. Tellinghuisen
from: Hepatitis C: Antiviral Drug Discovery and Development (Edited by: Seng-Lai Tan and Yupeng He). Caister Academic Press, U.K. (2011)
The hepatitis C virus (HCV) is a significant public health problem of international scope. HCV is capable of establishing chronic infections in the majority of those infected, resulting in progressive liver damage and a host of extra-hepatic disorders. Current drug therapies are ineffective in clearing infections from the majority of patients, highlighting the need for better anti-viral drugs. Recent developments in HCV genetic systems have led to significant advances in our understanding of the life cycle of this important pathogen, and it is this understanding that will ultimately lead to better anti-viral strategies. It is the purpose of this chapter to provide an overview of the life cycle of HCV, with a focus on aspects of the viral life cycle that might be amenable to future drug therapies read more ...