Transcriptional Regulatory Network in Pseudomonas aeruginosa
Deepak Balasubramanian, Senthil Kumar Murugapiran, Eugenia Silva-Herzog, Lisa Schneper, Xing Yang, Gorakh Tatke, Giri Narasimhan and Kalai Mathee
from: Bacterial Gene Regulation and Transcriptional Networks (Edited by: M. Madan Babu). Caister Academic Press, U.K. (2013)
Pseudomonas aeruginosa is found in a wide range of habitats, primarily in soil and water and is the epitome of opportunistic human pathogens. A myriad of virulence factors produced by the bacterium ensure its success as a pathogen. P. aeruginosa has one of the largest genomes among eubacteria and transcriptional regulators comprise about 8% of the genome. Sequence analysis of the regulators belonging to different families shows clustering while network analysis shows extensive crosstalk, and reveals empirically identified and novel interactions between regulators. Gene expression in P. aeruginosa is an intricately interlinked process and is exemplified in the regulation of virulence factor expression. Major regulatory processes such as quorum sensing involving multiple regulators translate external signals perceived by the bacterium into gene expression/repression via regulatory cascades. Many global regulators have been identified that serve to link different virulence systems. Understanding the role of the as yet uncharacterized transcriptional regulatory proteins will provide important insights into the physiology of this important human pathogen and has potential therapeutic implications read more ...