The Transcriptional Regulatory Network of Mycobacterium tuberculosis
Gábor Balázsi, Oleg A. Igoshin, and Maria Laura Gennaro
from: Bacterial Gene Regulation and Transcriptional Networks (Edited by: M. Madan Babu). Caister Academic Press, U.K. (2013)
Approximately one third of the world's human population is infected with Mycobacterium tuberculosis. Most infected individuals have latent infection: they do not show symptoms and carry bacteria that survived the immune response and are mostly dormant. When the immune response weakens, dormant bacteria can reactivate and cause a life-threatening disease. If the mechanisms of dormancy were better understood, disease reactivation and spreading could be prevented. Here we review our recent work on two mycobacterial survival strategies that are probably related to dormancy: environmental sensing followed by stress response and stochastically delayed switching into dormancy. We discuss the use of large-scale regulatory networks to infer how hypoxia affects the mycobacterial transcriptome at the genomic scale. We also show how sigma factor sequestration by the corresponding anti-sigma factor may generate a nonlinear response, which results in bistability when combined with positive feedback read more ...