Bacillus subtilis Transcriptional Network
Yuko Makita and Kenta Nakai
from: Bacterial Gene Regulation and Transcriptional Networks (Edited by: M. Madan Babu). Caister Academic Press, U.K. (2013)
Bacillus subtilis is a soil living bacterium, long known as a representative of the low G+C group of Gram-positive bacteria in contrast to Escherichia coli, a representative of Gram-negative bacteria. Its genome contains about 4,176 protein-coding genes and 178 RNA genes. The number of sigma factors is 18, which is much larger than 7 in E. coli. Although there are very few theoretical studies of its global transcriptional network, our preliminary analysis based on experimentally validated data stored in the DBTBS database suggests that it is a typical scale-free network largely governed by a small number of hub transcription factors like that of many other model organisms. However, some of the results of the network motif analysis in E. coli were not confirmed in B. subtilis. Although this is likely to be due to the small sample size in B. subtilis, a more cautious approach might be necessary to perform network motif analyses of bacterial gene regulatory networks, which are not so large, in general. As a specific sub-network, the gene regulatory network for sporulation, which is regarded as a model of eukaryotic differentiation process, is described. In the description of the network, not only transcriptional regulation but also post-translational regulation as well as genome recombination are necessary read more ...