Genomic Approaches to Reconstructing Transcriptional Networks
Stephen J. W. Busby and Stephen D. Minchin
from: Bacterial Gene Regulation and Transcriptional Networks (Edited by: M. Madan Babu). Caister Academic Press, U.K. (2013)
The traditional methods for discovering transcriptional regulatory networks in bacteria, based on genetics and biochemistry, are now being replaced by high throughput pan-genome methods. Experimental approaches include methods involving RNA or methods based on the direct observation of transcription factors. This chapter places the new methods in context and discusses their potential benefits and drawbacks read more ...