Caister Academic Press

Current Progress in the Inactivation of Endotoxin and Lipid A by Exposure to Nitrogen Gas Plasma

Hideharu Shintani
from: Gas Plasma Sterilization in Microbiology: Theory, Applications, Pitfalls and New Perspectives (Edited by: Hideharu Shintani and Akikazu Sakudo). Caister Academic Press, U.K. (2016) Pages: 41-50.


Nitrogen gas plasma treatment has sporicidal activity as well as the ability to inactivate endotoxins and lipid A. The mechanism of nitrogen gas plasma sterilization may include synergistic effects involving free radicals (e.g. OH, NO or OONO radicals) and metastable species (i.e., metastable states of N2 or O2). Exposure to nitrogen gas plasma caused no discernable deterioration in the functional compatibility of various materials under investigation. Based on these findings, nitrogen gas plasma sterilization is a promising method for the sterilization of medical devices read more ...
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