Caister Academic Press

Theoretical Background and Mode of Action of Gas Plasma Sterilization

Hideharu Shintani
from: Gas Plasma Sterilization in Microbiology: Theory, Applications, Pitfalls and New Perspectives (Edited by: Hideharu Shintani and Akikazu Sakudo). Caister Academic Press, U.K. (2016) Pages: 5-12.


In this chapter theoretical background and potential mode of action of gas plasma sterilization are described. Nowadays, gas plasma sterilization is widely utilized for sterilization of spores. Because spores are more tolerant than vegetative bacterial cells, bacterial endospores are used as the biological indicator (BI). Geobacillus stearothermophilus ATCC 7953 is generally used as the BI for gas plasma sterilization. Gas plasma sterilization penetration is quite shallow, ie., ~ 10-20 nm from the surface, so it is easy to achieve a sterility assurance level (SAL) of 10-6 and material/functional compatibility compared with alternative sterilization procedures. Simultaneous achievement of a SAL of 10-6 and material/functional compatibility will be discussed in detail in Chapter 3 read more ...
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