Caister Academic Press

A Molecular Update on the Pathogenesis of Candidiasis

Duncan Wilson and Bernhard Hube
from: Human Pathogenic Fungi: Molecular Biology and Pathogenic Mechanisms (Edited by: Derek J. Sullivan and Gary P. Moran). Caister Academic Press, U.K. (2014)


In contrast to most of the human pathogenic fungi described in this book, pathogenic species of the genus Candida do not normally exist in ecological niches such as soil or compost. Instead, these fungi have evolved in close association with warm-blooded animals, such as humans. For most people, at most times, these yeasts exist as harmless members of the microbiome. However, some species are capable of causing devastating infections in their human hosts. In this chapter we summarise and discuss important recent developments that have been made in our understanding of the molecular basis of Candida pathogenicity, with an emphasis on the dominant pathogenic species, Candida albicans read more ...
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