Caister Academic Press

Comparative Pathogenesis: Transcriptomic Analyses of Host Cell-Fungus Interactions

Elaine Bignell
from: Human Pathogenic Fungi: Molecular Biology and Pathogenic Mechanisms (Edited by: Derek J. Sullivan and Gary P. Moran). Caister Academic Press, U.K. (2014)


The contribution of host activities to positive, and negative, outcomes of fungal disease is increasingly recognised. Technological advances are permitting scientists to unravel gene-by-gene the complexities of the host-pathogen interaction, an objective which will remain a crucial component of infectious disease research for the foreseeable future, and will likely yield a new generation of immunotherapeutic antifungal entities. The fungal host-pathogen interaction includes a remarkable array of behaviours from pathogen-mediated killing of host cells, to intracellular occupancy and lytic expulsion, behaviours which drive the outcomes of disease by governing pathogen replication, immune evasion, survival, and dissemination. This chapter will explore the fruits of transcriptomic analyses of fungal host-pathogen interactions read more ...
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