Molecular Pathogenesis, Epidemiology and Drug Resistance of Shigella species
G. P. Pazhani and T. Ramamurthy
from: Foodborne and Waterborne Bacterial Pathogens: Epidemiology, Evolution and Molecular Biology (Edited by: Shah M. Faruque). Caister Academic Press, U.K. (2012)
Shigella species are often associated with diarrhoea/dysentery among children in developing countries of Asia-African regions and also cause foodborne infections in developed countries. During infection, this pathogen secretes a number of effectors via the type III secretion system. Recently, Shigella-infected cases have increased considerably in Asia, but the death rate decreased substantially due to nutritional and clinical interventions. Antimicrobials reduce the episodes of shigellosis. However, multiple antibiotic resistance in shigellae have increased over the years due to improper use of antimicrobials in the treatment of diarrhoea. Several mechanisms such as plasmids and other mobile genetic elements are involved in the transmission of resistance in shigellae. Due to poor efficacy of many of the existing Shigella vaccines, none has been licensed for use in endemic areas. This chapter reviews our current understanding of mechanism involved in the pathogenesis of Shigella, antimicrobial resistance and also its epidemiological importance and clinical management of shigellosis read more ...