Antiviral Therapies for Foot-and-mouth Disease
Annebel R. De Vleeschauwer, David J. Lefebvre and Kris De Clercq
from: Foot-and-Mouth Disease Virus: Current Research and Emerging Trends (Edited by: Francisco Sobrino and Esteban Domingo). Caister Academic Press, U.K. (2017) Pages: 357-384.
Prevention and control of foot-and mouth disease (FMD) is traditionally based on zoo-sanitary measures and vaccination. The genetic and antigenic diversity of the FMD virus (FMDV), its highly infectious nature and enormous dynamic potential illustrate that pan-serotype targeted control measures inhibiting viral replication immediately upon administration would be a valuable support tool or alternative to vaccination to smother FMD outbreaks in an early stage. In this respect, antiviral drugs against FMDV come into focus. Many research groups have pursued various approaches in search of anti-FMD therapies. Although the research topic is rather young some encouraging achievements have been reported, but for all approaches several issues still need to be addressed before reliable practical application can be reached. In this chapter we review the history and the state of the art of antiviral drugs against FMDV. Nucleoside analogues, small chemical molecules, oligonucleotides, new molecular biological techniques such as RNA interference, single-domain antibodies and derivatives from natural products are covered. Overall challenges and strengths and weaknesses specific to the different approaches are discussed read more ...