The Foot-and-mouth Disease Virion: Structure and Function
Mauricio G. Mateu
from: Foot-and-Mouth Disease Virus: Current Research and Emerging Trends (Edited by: Francisco Sobrino and Esteban Domingo). Caister Academic Press, U.K. (2017) Pages: 61-106.
X-ray crystallography, cryoelectron microscopy, nuclear magnetic resonance spectroscopy or a combination of methods have been used to determine the structure of foot-and-mouth disease virus (FMDV) virions, capsids and capsid components, and their complexes with receptors or antibodies. Interpretation and comparison of the structures solved, together with the results of many structure-based biophysical, biochemical and biological studies on the properties and functions of FMDV virions and their components, have greatly increased our understanding of FMDV biology in atomic detail. This knowledge is also facilitating the development of better anti-FMD vaccines, and may help the design of anti-FMDV drugs. The present chapter reviews the structure of the FMDV virion and many structural aspects related with different steps of the infectious cycle in which the virion participates: morphogenesis, maintenance of physical integrity, interaction with antibodies and escape from antibody recognition, recognition of cellular receptors, and viral genome uncoating. The production of FMDV empty capsids and the structure-based engineering of FMDV virions and empty capsids for the development of improved or novel anti-FMD vaccines are also reviewed read more ...