Influenza Virus Replication and Transcription
Jaime Martin-Benito, Frank T. Vreede and Juan Ortin
from: Influenza: Current Research (Edited by: Qinghua Wang and Yizhi Jane Tao). Caister Academic Press, U.K. (2016) Pages: 17-40.
The influenza A viruses are members of the Orthomyxoviridae family that cause respiratory infections in humans. They appear as yearly epidemics and occasional pandemics, which constitute a serious health problem and generate an important economic burden. The virus genome consists of eight single-stranded, negative-polarity RNAs that associate to the RNA polymerase complex and the nucleoprotein to form megaDalton sized ribonucleoprotein particles (RNPs). Here we describe the structure of these RNPs, their constitutive elements and the interactions among them. In addition, we discuss the mechanisms by which the RNPs transcribe and replicate the viral genome, including the potential participation of cellular host factors read more ...